C-H 18F-fluorination of 8-methylquinolines with Ag[18F]F

被引：16

作者：

Lee, So Jeong ^{[1
]}

Brooks, Allen F. ^{[1
]}

Ichiishi, Naoko ^{[2
]}

Makaravage, Katarina J. ^{[2
]}

Mossine, Andrew, V ^{[1
]}

Sanford, Melanie S. ^{[2
]}

Scott, Peter J. H. ^{[1
]}

机构：

[1] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 20期

关键词：

LATE-STAGE; FLUORIDE-ION; FLUORINATION; F-18; FLUOROALKANES;

D O I：

10.1039/c9cc00641a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This report describes a Pd-mediated C-H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[F-18]F. To achieve this transformation, a new method was developed for the generation of Ag[F-18]F using a sep-pak cartridge. The C-H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module.

引用

页码：2976 / 2979

页数：4

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