Structural Diversity and Biological Activities of Novel Secondary Metabolites from Endophytes

被引:76
|
作者
Gao, Han [1 ]
Li, Gang [1 ]
Lou, Hong-Xiang [1 ,2 ]
机构
[1] Qingdao Univ, Sch Pharm, Dept Nat Med & Pharmacognosy, Qingdao 266021, Peoples R China
[2] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Nat Prod Chem,Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China
来源
MOLECULES | 2018年 / 23卷 / 03期
关键词
endophytes; natural products; skeletons; biosynthesis; bioactivities; ECHINORUBER SP-NOV; 5-MEMBERED B RING; HPLC-SPE-NMR; NATURAL-PRODUCTS; A-C; ABSOLUTE-CONFIGURATIONS; SPIRO-MAMAKONE; DIKETOPIPERAZINE ALKALOIDS; BIOMIMETIC SYNTHESIS; STRUCTURE REVISION;
D O I
10.3390/molecules23030646
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Exploration of structurally novel natural products greatly facilitates the discovery of biologically active pharmacophores that are biologically validated starting points for the development of new drugs. Endophytes that colonize the internal tissues of plant species, have been proven to produce a large number of structurally diverse secondary metabolites. These molecules exhibit remarkable biological activities, including antimicrobial, anticancer, anti-inflammatory and antiviral properties, to name but a few. This review surveys the structurally diverse natural products with new carbon skeletons, unusual ring systems, or rare structural moieties that have been isolated from endophytes between 1996 and 2016. It covers their structures and bioactivities. Biosynthesis and/or total syntheses of some important compounds are also highlighted. Some novel secondary metabolites with marked biological activities might deserve more attention from chemists and biologists in further studies.
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页数:31
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