Binding of DC-SIGN to the Hemagglutinin of Influenza A Viruses Supports Virus Replication in DC-SIGN Expressing Cells

被引:39
|
作者
Hillaire, Marine L. B. [1 ]
Nieuwkoop, Nella J. [1 ]
Boon, Adrianus C. M. [3 ]
de Mutsert, Gerrie [1 ]
Vogelzang-van Trierum, Stella E. [1 ]
Fouchier, Ron A. M. [1 ]
Osterhaus, Albert D. M. E. [1 ,2 ]
Rimmelzwaan, Guus F. [1 ,2 ]
机构
[1] Erasmus MC, Rotterdam, Netherlands
[2] Viroclin Biosci BV, Rotterdam, Netherlands
[3] Erasmus MC, Rotterdam, Netherlands
来源
PLOS ONE | 2013年 / 8卷 / 02期
关键词
HUMAN DENDRITIC CELLS; RESPIRATORY SYNDROME CORONAVIRUS; N-LINKED GLYCOSYLATION; RECEPTOR-BINDING; IN-VITRO; MANNOSE RECEPTOR; STRUCTURAL BASIS; TRANS-INFECTION; ENTRY; RECOGNITION;
D O I
10.1371/journal.pone.0056164
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Dendritic cells express lectins receptors, like DC-SIGN, which allow these cells to sense glycans that are present on various bacterial and viral pathogens. Interaction of DC-SIGN with carbohydrate moieties induces maturation of dendritic cells and promotes endocytosis of pathogens which is an important property of these professional antigen presenting cells. Uptake of pathogens by dendritic cells may lead to cross-presentation of antigens or infection of these cells, which ultimately results in activation of virus-specific T cells in draining lymph nodes. Little is known about the interaction of DC-SIGN with influenza A viruses. Here we show that a virus with a non-functional receptor binding site in its hemagglutinin, can replicate in cells expressing DC-SIGN. Also in the absence of sialic acids, which is the receptor for influenza A viruses, these viruses replicate in DC-SIGN expressing cells including human dendritic cells. Furthermore, the efficiency of DC-SIGN mediated infection is dependent on the extent of glycosylation of the viral hemagglutinin.
引用
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页数:10
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