Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase

被引：280
|
作者：
Hu, JM
Seeger, C
机构：
[1] Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 03期
关键词：
D O I：
10.1073/pnas.93.3.1060
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The heat shock protein Hsp90 is known as an essential component of several signal transduction pathways and has now been identified as an essential host factor for hepatitis B virus replication. Hsp90 interacts with the viral reverse transcriptase to facilitate the formation of a ribonucleoprotein (RNP) complex between the polymerase and an RNA ligand, This RNP complex is required early in replication for viral assembly and initiation of DNA synthesis through a protein-priming mechanism. These results thus invoke a role for the Hsp90 pathway in the formation of an RNP.
引用
收藏
页码：1060 / 1064
页数：5
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