Introduction University students are subjected to different kinds of stressors, i.e.academic pressures, social issues and financial problems. This can affect their academic achievements and quality of life. Objective The aim of this study was to determine the health-related quality of life of university students, and how it is affected by the presence of chronic diseases, mental disorders comorbidity, and patterns of medical services use Methods This web based study included a sample of 1A10 Slovenian university students. We used a j self-administered questionnaire, containing a sheet with demographic data Zung's self-assessment inventories about anxiety and depression, and EQ-50 questionnaire The main outcome measures were scores on EQ-5D part and VAS part of the EQ-5D questionnaire Results Independent factors associated with the health related quality Of life of university students, were the presence of chronic pain, the presence of depression and anxiety, need for urgent medical help and at least one visit to a clinical specialist in the past year The independent factors associated with the health status of university students were the presence of chronic diseases, chronic pain, depression and anxiety, a visit to a clinical specialist a need for urgent medical help and a visit to an emergenty unit in the past year. Conclusion Health related quality of life of university students can be seriously affected by the presence I of mental disorders and chronic pain: Appropriate health related measures should be adopted to achieve early recognition of worse health related quality of life, the presence of mental disorders and other chronic conditions, and to enable their effective treatment