Silver-Mediated [3+2] Cycloaddition of Alkynes and N-Isocyanoiminotriphenylphosphorane: Access to Monosubstituted Pyrazoles

被引：44

作者：

Yi, Fanhua ^{[1
]}

Zhao, Wanjun ^{[1
]}

Wang, Zikun ^{[1
]}

Bi, Xihe ^{[1
,2
]}

机构：

[1] Northeast Normal Univ, Dept Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Jilin, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 09期

基金：

中国国家自然科学基金;

关键词：

PROPARGYLIC ALCOHOLS; ONE-POT; REGIOSELECTIVE SYNTHESIS; TERMINAL ALKYNES; DUAL ROLES; ISOCYANIDES; DERIVATIVES; PYRROLES; (N-ISOCYANIMINO)TRIPHENYLPHOSPHORANE; ACID;

D O I：

10.1021/acs.orglett.9b00860

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A silver-mediated [3 + 2] cycloaddition of "CNN" and "C C" for constructing pyrazoles has been described. The "CNN" building block used is N-isocyanoiminotriphenylphosphorane, which is a stable, safe, easy-to-handle, and odorless solid isocyanide. The reaction is characterized by its mild conditions, broad substrate scope, and excellent functional group tolerance.

引用

页码：3158 / 3161

页数：4

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