Treatment of Super-Refractory Status Epilepticus

被引：30
|
作者：
Bayrlee, Ahmad [1 ]
Ganeshalingam, Nimalya [1 ]
Kurczewski, Lisa [2 ]
Brophy, Gretchen M. [2 ]
机构：
[1] Virginia Commonwealth Univ, Dept Neurol, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Dept Pharm, Richmond, VA 23298 USA
来源：
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2015年 / 15卷 / 10期
关键词：
Status epilepticus (SE); Super-refractory status epilepticus (SRSE); Gamma-aminobutyric acid (GABA); Antiepileptic drug (AED); Pharmacotherapy; Adverse drug events; TRANSCRANIAL MAGNETIC STIMULATION; VAGUS NERVE-STIMULATION; ELECTROCONVULSIVE-THERAPY; KETOGENIC DIET; INTRAVENOUS LACOSAMIDE; ADULTS; KETAMINE; EPILEPSY; EFFICACY; CHILDREN;
D O I：
10.1007/s11910-015-0589-2
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Super-refractory status epilepticus (SRSE) is a devastating neurological condition with limited treatment options. We conducted an extensive literature search to identify and summarize the therapeutic options for SRSE. The search mainly resulted in case reports of various pharmacologic and non-pharmacologic treatments. The success rate of each of the following agents, ketamine, inhaled anesthetics, intravenous immunoglobulin G (IVIG), IV steroids, ketogenic diet, hypothermia, electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), and vagal nerve stimulation (VNS), are discussed in greater detail. The choice of appropriate treatment options for a given patient is based on clinical presentation. This review focuses on evidence-based, pharmacotherapeutic strategies for patients in SRSE.
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页数：9
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