Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling

被引：4

作者：

Zhao, Shumei ^{[1
,2
]}

Luo, Jiaqi ^{[1
,2
]}

Hu, Jun ^{[1
,2
]}

Wang, Hesheng ^{[1
,2
]}

Zhao, Ningwei ^{[1
,3
]}

Cao, Meng ^{[2
,4
]}

Zhang, Cong ^{[1
,2
]}

Hu, Rongkui ^{[1
,2
]}

Liu, Lanying ^{[1
,2
]}

机构：

[1] Affiliated Hosp Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Nanjing 210029, Peoples R China

[2] Nanjing Univ Chinese Med, Nanjing 210029, Peoples R China

[3] Shimadzu Biomed Res Lab, Shanghai 200233, Peoples R China

[4] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Nanjing 210028, Peoples R China

来源：

MEDIATORS OF INFLAMMATION | 2022年 / 2022卷

基金：

中国国家自然科学基金;

关键词：

PROTEIN-KINASE-A; EPITHELIAL-MESENCHYMAL TRANSITION; TRANSMEMBRANE CONDUCTANCE REGULATOR; N-TERMINAL DOMAIN; ERM PROTEINS; TYROSINE PHOSPHORYLATION; SIGNALING PATHWAY; STRUCTURAL BASIS; CELL-ADHESION; SMOOTH-MUSCLE;

D O I：

10.1155/2022/6255012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ezrin is an actin binding protein connecting the cell membrane and the cytoskeleton, which is crucial to maintaining cell morphology, intercellular adhesion, and cytoskeleton remodeling. Asthma involves dysfunction of inflammatory cells, cytokines, and airway structural cells. Recent studies have shown that ezrin, whose function is affected by extensive phosphorylation and protein interactions, is closely associated with asthma, may be a therapeutic target for asthma treatment. In this review, we summarize studies on ezrin and discuss its role in asthma-related airway inflammation and remodeling.

引用

页数：11

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