Variation in the purinergic P2RX7 receptor gene and schizophrenia

被引：20
|
作者：
Hansen, Thomas [1 ,8 ]
Jakobsen, Klaus D. [1 ,8 ,9 ]
Fenger, Mogens [2 ]
Nielsen, Jimmi [3 ]
Krane, Karoline [1 ,4 ]
Fink-Jensen, Anders [4 ]
Lublin, Henrik [5 ]
Ullum, Henrik
Timm, Sally [6 ]
Wang, August G. [7 ]
Jorgensen, Niklas Rye [2 ]
Werge, Thomas [1 ]
机构：
[1] Copenhagen Univ Hosp, Mental Hlth Ctr Sct Hans, Res Inst Biol Psychiat, DK-4000 Roskilde, Denmark
[2] Copenhagen Univ Hosp, Dept Clin Biochem & Endocrinol, DK-2650 Hvidovre, Denmark
[3] Aalborg Psychiat Hosp, Unit Psychiat Res, DK-9000 Aalborg, Denmark
[4] Copenhagen Univ Hosp, Rigshosp, Mental Hlth Ctr, DK-2100 Copenhagen O, Denmark
[5] Copenhagen Univ Hosp, Mental Hlth Ctr Glostrup, DK-2600 Glostrup, Denmark
[6] Copenhagen Univ Hosp, Mental Hlth Ctr Frederiksberg, DK-2000 Frederiksberg, Denmark
[7] Copenhagen Univ Hosp, Mental Hlth Ctr Amager, DK-2300 Copenhagen S, Denmark
[8] Univ Copenhagen, Ctr Pharmacogenom, DK-2200 Copenhagen N, Denmark
[9] Copenhagen Univ Hosp, Mental Hlth Ctr Hvidovre, DK-2650 Hvidovre, Denmark
来源：
SCHIZOPHRENIA RESEARCH | 2008年 / 104卷 / 1-3期
关键词：
purinergic receptor; P2XR(7); treatment resistance; register data;
D O I：
10.1016/j.schres.2008.05.026
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Introduction: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. Methods: Nine functionally characterised variants in P2RX(7) were genotyped it) 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. Results: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. Conclusion: P2XR(7) was not associated with schizophrenia in this study. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：146 / 152
页数：7
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