Advanced diagnostic methods in oral and maxillofacial pathology. Part II: Immunohistochemical and immunofluorescent methods

被引:26
|
作者
Jordan, RCK
Daniels, TE
Greenspan, JS
Regezi, JA
机构
[1] Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
关键词
D O I
10.1067/moe.2002.119567
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The practice of pathology is currently undergoing significant change, in large part clue to advances in the analysis of DNA, RNA, and proteins in tissues. These advances have permitted improved biologic insights inter many developmental, inflammatory, metabolic, infectious, and neoplastic diseases. Moreover, molecular analysis has also led to improvements in the accuracy of disease diagnosis and classification. It is likely that, in the future, these methods will increasingly enter into the day-to-day diagnosis and management of patients. The pathologist will continue to play a fundamental role in diagnosis and will likely be in a pivotal position to guide the implementation and interpretation of these tests as they move from the research laboratory into diagnostic pathology. The purpose of this 2-part series is to provide an overview of the principles and applications of current molecular biologic and immunologic tests. In Part I, the biologic fundamentals of DNA, RNA, and proteins and methods that are currently available or likely to become available to the pathologist in the next several years for their isolation and analysis in tissue biopsies were discussed. In part II, advances in immunohistochemistry and immunofluorescence methods and their application to modern diagnostic pathology are reviewed.
引用
收藏
页码:56 / 74
页数:19
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