Relationship Between Augmentation Index and Left Ventricular Diastolic Function in Healthy Women and Men

被引:17
|
作者
Higashi, Haruhiko [1 ,2 ]
Okayama, Hideki [3 ]
Saito, Makoto [1 ]
Morioka, Hiroe [1 ]
Aono, Jun [1 ]
Yoshii, Toyofumi [1 ]
Hiasa, Go [3 ]
Sumimoto, Takumi [1 ]
Nishimura, Kazuhisa [2 ]
Inoue, Katsuji [2 ]
Ogimoto, Akiyoshi [2 ]
Higaki, Jitsuo [2 ]
机构
[1] Kitaishikai Hosp, Dept Cardiol, Ozu, Japan
[2] Ehime Univ, Grad Sch Med, Dept Cardiol Pulmonol Hypertens & Nephrol, Toon, Japan
[3] Ehime Prefectural Cent Hosp, Dept Cardiol, Matsuyama, Ehime, Japan
关键词
arterial stiffness; augmentation index; blood pressure; diastolic function; hypertension; sex difference; GENDER-RELATED DIFFERENCES; PULSE-WAVE VELOCITY; HEART-FAILURE; EJECTION FRACTION; AORTIC STIFFNESS; PRESSURE; ECHOCARDIOGRAPHY; ASSOCIATION; REFLECTION; OVERWEIGHT;
D O I
10.1093/ajh/hpt115
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The aim of this study was to investigate the effect of sex on the correlation between arterial stiffness and left ventricular (LV) diastolic function in a healthy population without significant atherosclerosis. Subjects (n 446) who had simultaneous echocardiography and arterial stiffness recordings were enrolled. From these subjects, 95 men and 72 age-matched women without atherosclerotic risk factors (hypertension, dyslipidemia, and diabetes mellitus) were included in the analysis. We measured brachialankle pulse wave velocity (baPWV) and carotid augmentation index (AIx) as arterial stiffness parameters. Peak early diastolic mitral annular velocity (e) was significantly correlated with baPWV (men: r 0.428, P < 0.001; women: r 0.515, P < 0.001) and carotid AIx (men: r 0.295, P 0.004; women: r 0.558, P < 0.001). The ratio of early diastolic mitral flow velocity to e (E/e) was significantly correlated with both arterial stiffness parameters in women but not men. Multivariable regression analysis revealed carotid AIx ( 0.257; P 0.02) was a significant independent predictor of e in women but not men. These results suggest that the correlation between AIx and LV diastolic function is stronger in women than men in a healthy population.
引用
收藏
页码:1280 / 1286
页数:7
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