High-sensitivity ultrasound-modulated optical tomography with a photorefractive polymer

被引：13
|
作者：
Suzuki, Yuta [1 ]
Lai, Puxiang [1 ]
Xu, Xiao [1 ]
Wang, Lihong [1 ]
机构：
[1] Dept Biomed Engn, St Louis, MO 63130 USA
来源：
OPTICS LETTERS | 2013年 / 38卷 / 06期
基金：
美国国家卫生研究院;
关键词：
BIOLOGICAL TISSUES; SCATTERING MEDIA; DIFFUSE MEDIA; TURBID MEDIA; PHOTONS; LIGHT; LASER;
D O I：
10.1364/OL.38.000899
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
By detecting ultrasonically tagged diffuse light, ultrasound-modulated optical tomography images optical contrast with ultrasonic resolution deep in turbid media, such as biological tissue. However, small detection etendues and weak tagged light submerged in strong untagged background light limit the signal detection sensitivity. In this Letter, we report the use of a large-area (similar to 5 cm x 5cm) photorefractive polymer film that yields more than 10 times detection etendue over previous detection schemes. Our polymer-based system enabled us to resolve absorbing objects embedded inside diffused media thicker than 80 transport mean free paths, by using moderate light power and short ultrasound pulses. (C) 2013 Optical Society of America
引用
收藏
页码：899 / 901
页数：3
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