Large-Scale CRISPR-Cas Genome-Wide Activity Profiling in Human Primary T-Cells Reveals Genetic and Epigenetic Determinants of Off-Target Effects

被引:0
|
作者
Lazzarotto, Cicera R. [1 ]
Malinin, Nikolay L. [1 ]
Katta, Varun [1 ]
Qi, Qian [1 ]
Cheng, Yong [1 ]
Tsai, Shengdar Q. [1 ]
机构
[1] St Jude Childrens Res Hosp, Hematol, 332 N Lauderdale St, Memphis, TN 38105 USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
8
引用
收藏
页码:5 / 6
页数:2
相关论文
共 26 条
  • [1] Large-Scale CRISPR-Cas Genome-Wide Activity Profiling in Human Primary T-Cells Reveals Genetic and Epigenetic Determinants of Genome-Wide Nuclease Activity
    Lazzarotto, Cicera
    Malinin, Nikolay
    Li, Yichao
    Hang, Ruochi Z.
    Yang, Yang
    Lee, GaHyun
    Cowley, Eleanor
    He, Yanghua
    Lan, Xin
    Jividen, Kasey
    Katta, Varun
    Kolmakova, Natalia
    Petersen, Chris
    Qi, Qian
    Strelcov, Evgheni
    Maragh, Samantha
    Krenciute, Giedre
    Ma, Jian
    Cheng, Yong
    Tsai, Shengdar
    MOLECULAR THERAPY, 2020, 28 (04) : 227 - 228
  • [2] Large-scale genome-wide CHANGE-seq profiling of CRISPR-Cas9 therapeutic targets reveals genetic and epigenetic determinants of activity
    Lazzarotto, Cicera R.
    Malinin, Nikolay
    Katta, Varun
    Li, Yichao
    Cheng, Yong
    Tsai, Shengdar Q.
    TRANSGENIC RESEARCH, 2020, 29 (04) : 473 - 473
  • [3] GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
    Tsai, Shengdar Q.
    Zheng, Zongli
    Nguyen, Nhu T.
    Liebers, Matthew
    Topkar, Ved V.
    Thapar, Vishal
    Wyvekens, Nicolas
    Khayter, Cyd
    Iafrate, A. John
    Le, Long P.
    Aryee, Martin J.
    Joung, J. Keith
    NATURE BIOTECHNOLOGY, 2015, 33 (02) : 187 - 197
  • [4] GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
    Shengdar Q Tsai
    Zongli Zheng
    Nhu T Nguyen
    Matthew Liebers
    Ved V Topkar
    Vishal Thapar
    Nicolas Wyvekens
    Cyd Khayter
    A John Iafrate
    Long P Le
    Martin J Aryee
    J Keith Joung
    Nature Biotechnology, 2015, 33 : 187 - 197
  • [5] Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
    Kim, Daesik
    Bae, Sangsu
    Park, Jeongbin
    Kim, Eunji
    Kim, Seokjoong
    Yu, Hye Ryeong
    Hwang, Jinha
    Kim, Jong-Il
    Kim, Jin-Soo
    NATURE METHODS, 2015, 12 (03) : 237 - +
  • [6] Digenome-seq: Genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
    Kim D.
    Bae S.
    Park J.
    Kim E.
    Kim S.
    Yu H.R.
    Hwang J.
    Kim J.-I.
    Kim J.-S.
    Nature Methods, 2015, 12 (3) : 237 - 243
  • [7] On- and off-target effects of paired CRISPR-Cas nickase in primary human cells
    Klermund, Julia
    Rhiel, Manuel
    Kocher, Thomas
    Chmielewski, Kay Ole
    Bischof, Johannes
    Andrieux, Geoffroy
    el Gaz, Melina
    Hainzl, Stefan
    Boerries, Melanie
    Cornu, Tatjana I.
    Koller, Ulrich
    Cathomen, Toni
    MOLECULAR THERAPY, 2024, 32 (05)
  • [8] Large-Scale GUIDE-seq-2 Profiling Reveals Effects of Human Genetic Variation on Cellular Off-Target Genome Editing Activity
    Lazzarotto, Cicera R.
    Li, Yichao
    Katta, Varun
    Obregon, Elizabeth Urbina
    Wood, Rachael
    Matsubara, Azusa
    Cheng, Yong
    Tsai, Shengdar Q.
    MOLECULAR THERAPY, 2023, 31 (04) : 64 - 65
  • [9] Genome-wide off-target analyses of CRISPR/Cas9-mediated T-cell receptor engineering in primary human T cells
    Kaeuferle, Theresa
    Stief, Tanja A.
    Canzar, Stefan
    Kutlu, Nayad N.
    Willier, Semjon
    Stenger, Dana
    Ferrada-Ernst, Paulina
    Habjan, Nicola
    Peters, Annika E.
    Busch, Dirk H.
    Feuchtinger, Tobias
    CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2022, 11 (01)
  • [10] CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity
    Cicera R. Lazzarotto
    Nikolay L. Malinin
    Yichao Li
    Ruochi Zhang
    Yang Yang
    GaHyun Lee
    Eleanor Cowley
    Yanghua He
    Xin Lan
    Kasey Jividen
    Varun Katta
    Natalia G. Kolmakova
    Christopher T. Petersen
    Qian Qi
    Evgheni Strelcov
    Samantha Maragh
    Giedre Krenciute
    Jian Ma
    Yong Cheng
    Shengdar Q. Tsai
    Nature Biotechnology, 2020, 38 : 1317 - 1327