Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology

被引：34
|
作者：
Kingston, Hugh W. F. [1 ,2 ]
Blacksell, Stuart D. [1 ,3 ]
Tanganuchitcharnchai, Ampai [1 ]
Laongnualpanich, Achara [4 ]
Basnyat, Buddha [5 ]
Day, Nicholas P. J. [1 ,3 ]
Paris, Daniel H. [1 ,3 ]
机构：
[1] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand
[2] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0909, Australia
[3] Churchill Hosp, Ctr Trop Med & Global Hlth, Nuffield Dept Clin Med, Oxford OX3 7LJ, England
[4] Chiangrai Prachanukhru Hosp, Chiangrai, Thailand
[5] Univ Oxford, Clin Res Unit, Patan Acad Hlth Sci, Kathmandu, Nepal
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2015年 / 22卷 / 10期
基金：
英国惠康基金;
关键词：
ORIENTIA-TSUTSUGAMUSHI; IMMUNE-RESPONSES; PCR ASSAY; INFECTION; DIAGNOSIS;
D O I：
10.1128/CVI.00390-15
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study investigated the comparative accuracy of a recombinant 56-kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies by using conventional serology in well-characterized serum samples from undifferentiated febrile illness patients. The RDT showed high specificity and promising comparative accuracy, with 82% sensitivity and 98% specificity for samples defined positive at an IgM indirect immunofluorescence assay positivity cutoff titer of >= 1:1,600 versus 92% and 95% at >= 1:6,400, respectively.
引用
收藏
页码：1130 / 1132
页数：3
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