Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion

被引：18
|
作者：
Kan, VL
Geber, A
Bennett, JE
机构：
[1] NIAID,CLIN MYCOL SECT,BETHESDA,MD 20892
[2] GEORGE WASHINGTON UNIV,MED CTR,DEPT MED,WASHINGTON,DC 20037
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 07期
关键词：
D O I：
10.1128/AAC.40.7.1717
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.
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页码：1717 / 1719
页数：3
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