Emerging Minimal-change Nephrotic Syndrome in a Patient with Chronic Mesangial Proliferative Lupus Nephritis

被引：11

作者：

Deji, Naoko ^{[1
]}

Sugimoto, Toshiro ^{[1
]}

Kanasaki, Masami ^{[1
]}

Aoyama, Masahiro ^{[1
]}

Tanaka, Yuki ^{[1
]}

Sakaguchi, Masayoshi ^{[1
]}

Nishio, Yoshihiko ^{[1
]}

Uzu, Takashi ^{[1
]}

Kashiwagi, Atsunori ^{[1
]}

机构：

[1] Shiga Univ Med Sci, Dept Internal Med, Otsu, Shiga 52021, Japan

来源：

INTERNAL MEDICINE | 2007年 / 46卷 / 13期

关键词：

mesangial proliferative lupus nephritis; minimal-change nephropathy; nephrotic syndrome; systemic lupus erythematosus;

D O I：

10.2169/internalmedicine.46.0028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 41-year-old Japanese woman with a 25-year history of systemic lupus erythematosus was admitted because of abrupt onset of nephrotic syndrome and acute renal failure. Renal biopsy specimen showed only mild mesangial proliferative glomerulonephritis associated with mesangial deposition of immunoglobulins/complements. No significant immune deposits were found in the glomerular capillary walls, but mild foot process effacement was observed on electron microscopy. Further, two-month corticosteroid therapy improved her massive proteinuria and renal dysfunction, indicating that this patient showed minimal-change nephropathy superimposed on mesangial proliferative lupus nephritis.

引用

页码：991 / 995

页数：5

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