Selection of Streptococcus pneumoniae mutants having reduced susceptibility to moxifloxacin and levofloxacin

被引：77
|
作者：
Li, XY [1 ]
Zhao, XL [1 ]
Drlica, K [1 ]
机构：
[1] Publ Hlth Res Inst, New York, NY 10016 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 02期
关键词：
D O I：
10.1128/AAC.46.2.522-524.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
With Streptococcus pneumoniae, moxifloxacin was 4- and 10-fold more effective than levofloxacin at restricting selection of resistant mutants and at killing resistant mutants, respectively. The selection frequency for first-step topoisomerase mutants was 1,000 times lower for moxifloxacin than for levofloxacin; this difference was lost when second-step mutants were selected.
引用
收藏
页码：522 / 524
页数：3
相关论文
共 50 条
  • [1] Pharmacodynamics of moxifloxacin, levofloxacin and sparfloxacin against Streptococcus pneumoniae
    Lister, PD
    Sanders, CC
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 47 (06) : 811 - 818
  • [2] Optimal killing of Streptococcus pneumoniae by gemifloxacin, levofloxacin and moxifloxacin
    Blondeau, JM
    Hansen, GT
    Metzler, KL
    Borsos, S
    Chau, J
    [J]. NOVEL PERSPECTIVES IN ANTIBACTERIAL ACTION, 2002, (76): : 15 - 26
  • [3] Streptococcus pneumoniae: susceptibility to penicillin and moxifloxacin
    Rossi, Flavia
    Gomes Franco, Maria Renata
    de Pina Rodrigues, Heleni Mota
    Andreazzi, Denise
    [J]. JORNAL BRASILEIRO DE PNEUMOLOGIA, 2012, 38 (01) : 66 - 71
  • [4] Single and multi-step resistance selection study in Streptococcus pneumoniae comparing ceftriaxone with levofloxacin, gatifloxacin and moxifloxacin
    Browne, FA
    Clark, C
    Bozdogan, B
    Dewasse, BE
    Jacobs, MR
    Appelbaum, PC
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2002, 20 (02) : 93 - 99
  • [5] Streptococcus pneumoniae response to repeated moxifloxacin or levofloxacin exposure in a rabbit tissue cage model
    Xuan, DW
    Zhong, MK
    Mattoes, H
    Bui, KQ
    McNabb, J
    Nicolau, DP
    Quintiliani, R
    Nightingale, CH
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (03) : 794 - 799
  • [6] MICs for Streptococcus pneumoniae with Reduced Penicillin Susceptibility
    Vicki A. Luna
    Marilyn C. Roberts
    [J]. Drugs, 1999, 58 : 381 - 382
  • [7] MICs for Streptococcus pneumoniae with reduced penicillin susceptibility
    Luna, VA
    Roberts, MC
    [J]. DRUGS, 1999, 58 (Suppl 2) : 381 - 382
  • [8] In vitro susceptibility of penicillin-resistant Streptococcus pneumoniae to levofloxacin, selection of resistant mutants, and time-kill synergy studies of levofloxacin combined with vancomycin, teicoplanin, fusidic acid, and rifampin
    Klugman, KP
    Capper, T
    Bryskier, A
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (12) : 2802 - 2804
  • [9] Susceptibility of multi-resistant Streptococcus pneumoniae to ciprofloxacin, ofloxacin and levofloxacin
    Fuchs, PC
    Barry, AL
    Brown, SD
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 39 (05) : 671 - 672
  • [10] Pharmacodynamics of moxifloxacin and levofloxacin at simulated epithelial lining fluid drug concentrations against Streptococcus pneumoniae
    Florea, NR
    Tessier, PR
    Zhang, CL
    Nightingale, CH
    Nicolau, DP
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (04) : 1215 - 1221
12345