Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review

被引：251
|
作者：
Quan, Taihao [1 ]
Fisher, Gary J. [1 ]
机构：
[1] Univ Michigan, Sch Med, Dept Dermatol, Ann Arbor, MI 48109 USA
来源：
GERONTOLOGY | 2015年 / 61卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Skin; Aging; Cysteine-rich protein 61; Age-associated dermal microenvironment; Collagen; Transforming growth factor-beta; Matrix metalloproteinases; Inflammaging; GROWTH-FACTOR-BETA; ABERRANT COLLAGEN HOMEOSTASIS; PHOTOAGED HUMAN SKIN; MATRICELLULAR PROTEIN; CCN PROTEINS; II RECEPTOR; FIBROBLASTS; IRRADIATION; CANCER; METALLOPROTEINASE-1;
D O I：
10.1159/000371708
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function. (C) 2015 S. Karger AG, Basel
引用
收藏
页码：427 / 434
页数：8
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