Emerging treatments in headache

被引：4
|
作者：
Diener, HC
Gendolla, A
Juptner, M
Kaube, H
Limmroth, V
机构：
[1] Department of Neurology, University of Essen
来源：
EUROPEAN NEUROLOGY | 1997年 / 38卷 / 03期
关键词：
migraine pathophysiology; experimental models; treatment of acute attack; migraine prophylaxis;
D O I：
10.1159/000113370
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recent PET studies performed in humans during migraine attacks revealed a 'spreading depression-like' oligemia in the occipital cortex during the aura phase and a region of increased blood flow in the brainstem during the headache phase. Animal models were established to test new migraine drugs. A number of 5-HT agonists, the so-called 'triptans', will be available in future besides sumatriptan to treat acute migraine attacks. Migraine prophylaxis is still hampered by the fact that we do not understand the action of drugs used for this purpose and do not have an animal model. Nevertheless, new substances were introduced recently into the prophylaxis of migraine.
引用
收藏
页码：167 / 174
页数：8
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