HBV-related hepatocellular carcinoma: the role of integration, viral proteins and miRNA

被引：2

作者：

Lim, Lucy ^{[1
,2
]}

Bang Manh Tran ^{[1
,3
]}

Vincan, Elizabeth ^{[1
,3
]}

Locarnini, Stephen ^{[1
]}

Warner, Nadia ^{[1
]}

机构：

[1] Victorian Infect Dis Reference Labs, Melbourne, Vic, Australia

[2] Austin Liver Transplant Unit, Heidelberg, Vic, Australia

[3] Univ Melbourne, Dept Anat & Neurosci, Canc Biol Lab, Parkville, Vic 3052, Australia

来源：

FUTURE VIROLOGY | 2012年 / 7卷 / 12期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

HBeAg; HBV; HBX; HCC; integration; miRNA; pre-S; HEPATITIS-B-VIRUS; PRE-S-REGION; NF-KAPPA-B; CORE NUCLEOTIDE-SEQUENCE; FAS-MEDIATED APOPTOSIS; INDUCIBLE NITRIC-OXIDE; DNA IN-VITRO; X-PROTEIN; SURFACE-ANTIGEN; NATURAL-HISTORY;

D O I：

10.2217/FVL.12.113

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The development of hepatocellular carcinoma during chronic hepatitis B infection is a multifactorial process thought to be a consequence of several direct and indirect mechanisms. In this review we discuss how viral proteins and cycles of ongoing liver damage and regeneration, coupled with HBV DNA integration and aberrant miRNA expression may enhance the risk for the development of hepatocellular carcinoma.

引用

页码：1237 / 1249

页数：13

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