Proliferation profile of endometrial polyps in post-menopausal women

被引：18
|
作者：
Maia, H [1 ]
Maltez, A [1 ]
Athayde, C [1 ]
Coutinho, EM [1 ]
机构：
[1] CEPARH, Endoscopy Unit, BR-40210341 Salvador, BA, Brazil
来源：
MATURITAS | 2001年 / 40卷 / 03期
关键词：
c-erbB2; endometrial polyps; Ki-67 proliferation marker;
D O I：
10.1016/S0378-5122(01)00247-X
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Objective: To determine whether or not the presence of c-erbB2 over-expression in endometrial polyps affects the percentage of cells positive for Ki-67 proliferation marker. Methods: Thirty-five patients with endometrial polyps were submitted to polypectomy by hysteroscopy. Ki-67 and c-erbB2 over-expression were investigated in the polyps by immunohistochemistry. Results: The presence of c-erbB2 over-expression by immunohistochemistry was observed in 80% of endometrial polyps and was associated with higher proliferation rates as determined by the number of positive Ki-67 cell nuclei. In c-erbB2-negative polyps, the proliferation rates were low. Conclusion: Ki-67 and c-erbB2 over-expression are frequent in endometrial polyps in post-menopausal women. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：273 / 281
页数：9
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