The pathogenic role of interleukin-27 in autoimmune diabetes

被引：30
|
作者：
Wang, R. [1 ]
Han, G. [1 ]
Wang, J. [1 ]
Chen, G. [1 ]
Xu, R. [1 ]
Wang, L. [1 ]
Li, X. [2 ]
Shen, B. [1 ]
Li, Y. [1 ]
机构：
[1] Inst Basic Med Sci, Dept Mol Immunol, Beijing 100850, Peoples R China
[2] Henan Univ, Sch Med, Inst Immunol, Kaifeng, Peoples R China
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 23期
关键词：
IL-27; autoimmune diabetes; IFN-gamma; IL-17; IL-4; TGF-beta; IL-10;
D O I：
10.1007/s00018-008-8540-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin (IL)-27 is an IL-12-related cytokine that can promote both anti- and pro-inflammatory immune responses. This study investigated the potential role of IL-27 in autoimmune diabetes. We detected a high level of IL-27 in diabetic NOD mice. In addition, blockade of IL-27 significantly delayed the onset of diabetic splenocyte-transferred diabetes, while IL-27-treated diabetic splenocytes promoted the onset of the disease, compared with untreated controls. Furthermore, IL-27 up-regulated pro-inflammatory cytokines IFN-gamma and IL-17 and down-regulated anti-inflammatory cytokines IL-4, TGF-beta, and IL-10 secreted by diabetic splenocytes. These results demonstrate a pathogenic role of IL-27 in T cell-mediated autoimmune diabetes.
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页码：3851 / 3860
页数：10
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