Catalytic enantioselective addition of organoaluminum reagents to aldehydes

被引：26
|
作者：
Fernandez-Mateos, Emilio
Macia, Beatriz [1 ]
Yus, Miguel
机构：
[1] Univ Alicante, Dept Quim Organ, E-03080 Alicante, Spain
来源：
TETRAHEDRON-ASYMMETRY | 2012年 / 23卷 / 10期
关键词：
GRIGNARD-REAGENTS; ASYMMETRIC HYDROSILYLATION; TRIALKYLALUMINUM ADDITION; DIORGANOZINC REAGENTS; CARBONYL-COMPOUNDS; KETONES; HYDROGENATION; COMPLEXES; ALKYLATION; REDUCTION;
D O I：
10.1016/j.tetasy.2012.05.007
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An efficient catalyst for the asymmetric addition of organoaluminum reagents to aldehydes is presented. The system is based on a readily available binaphthyl derivative as a chiral ligand and an excess of titanium tetraisopropoxide. The asymmetric methylation, ethylation, and propylation of a wide variety of aromatic and aliphatic aldehydes proceeded with good yields and with high enantioselectivities in a simple one-pot procedure under mild conditions. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：789 / 794
页数：6
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