Meta-analysis of randomized, double-blind, placebo-controlled, efficacy and safety studies of mirtazapine versus amitriptyline in major depression

A meta-analysis was performed on efficacy and safety data from 4 randomized, double-blind, 6-week, single-center studies comparing mirtazapine (n=194; 5-35 mg/day) with amitriptyline, (n=193, 40-280 mg/day) and placebo (n=193) in outpatients with a DSM-III diagnosis of major depressive episode. On all the main efficacy variables both active drugs consistently produced significantly greater improvements and significantly greater percentages of responders or remitters than place ho, The meta-analysis of adverse events shows that mirtazapine was better tolerated than amitriptyline, particularly with respect to anticholinergic and cardiac adverse events There were no differences between mirtazapine and placebo regarding the incidence of serotonergic adverse events. In conclusion. the results of this meta-analysis demonstrate that mirtazapine is as effective as amitriptyline but has a better tolerability profile.