A comparison of the effects of isoflurane and desflurane on the neuromuscular effects of mivacurium

被引：4
|
作者：
Kumar, N [1 ]
Mirakhur, RK [1 ]
Symington, MJ [1 ]
Loan, PB [1 ]
Connolly, FM [1 ]
机构：
[1] QUEENS UNIV BELFAST,DEPT ANAESTHET,BELFAST BT9 7BL,ANTRIM,NORTH IRELAND
来源：
ANAESTHESIA | 1996年 / 51卷 / 06期
关键词：
neuromuscular relaxants; mivacurium; anaesthetics; volatile; desflurane; isoflurane;
D O I：
10.1111/j.1365-2044.1996.tb12561.x
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
The effects of 1 MAC of desflurane and isoflurane (in 66% nitrous oxide) on the potency and duration of action of mivacurium were studied in 80 patients. The ED(95) of mivacurium was 86 mu g.kg(-1) (74-100) and 88 mu g.kg(-1) (76-103) (mean and 95% confidence intervals) during anaesthesia with desflurane and isoflurane respectively. The onset and duration of recovery to 25, 75 and 90% of T1 (first response in the TOF) of 200 mu g.kg(-1) of mivacurium were 1.4 (0.3) and 1.5 (0.3) min (mean and SD), 22 (4.9) and 19 (4.0), 29 (6.6) and 26 (5.8), and 32 (7.3) and 29 (6.6) min respectively. There was no significant difference in any of the variables between desflurane and isoflurane. It is concluded that the neuromuscular effects of mivacurium are similar during anaesthesia with 1 MAC of desflurane and isoflurane.
引用
收藏
页码：547 / 550
页数：4
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