The Microbial Zoo in the C-elegans Intestine: Bacteria, Fungi and Viruses

被引:35
|
作者
Jiang, Hongbing
Wang, David [1 ]
机构
[1] Washington Univ St Louis, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
来源
VIRUSES-BASEL | 2018年 / 10卷 / 02期
关键词
host-pathogen interaction; C; elegans; intestine; bacteria; fungi; viruses; microbiome; trans-kingdom interactions; INNATE IMMUNE-RESPONSE; PSEUDOMONAS-AERUGINOSA INFECTION; NEMATODE CAENORHABDITIS-ELEGANS; PROTEIN-COUPLED RECEPTOR; MAPK SIGNALING PATHWAY; RNA INTERFERENCE; VIRULENCE FACTORS; MODEL HOST; CRYPTOCOCCUS-NEOFORMANS; TRANSCRIPTION FACTOR;
D O I
10.3390/v10020085
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
C. elegans is an invaluable model organism that has been a driving force in many fundamental biological discoveries. However, it is only in the past two decades that it has been applied to host-pathogen interaction studies. These studies have been facilitated by the discoveries of natural microbes that infect C. elegans, including bacteria, fungi and viruses. Notably, many of these microbes share a common site of infection, the C. elegans intestine. Furthermore, the recent descriptions of a natural gut microbiota in C. elegans raise the possibility that this could be a novel model system for microbiome and trans-kingdom interaction studies. Here we review studies of C. elegans host-microbe interactions with a particular focus on the intestine.
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页数:12
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