The Microbial Zoo in the C-elegans Intestine: Bacteria, Fungi and Viruses
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作者:
Jiang, Hongbing
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机构:Washington Univ St Louis, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
Jiang, Hongbing
Wang, David
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Washington Univ St Louis, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ St Louis, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
Wang, David
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机构:
[1] Washington Univ St Louis, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
C. elegans is an invaluable model organism that has been a driving force in many fundamental biological discoveries. However, it is only in the past two decades that it has been applied to host-pathogen interaction studies. These studies have been facilitated by the discoveries of natural microbes that infect C. elegans, including bacteria, fungi and viruses. Notably, many of these microbes share a common site of infection, the C. elegans intestine. Furthermore, the recent descriptions of a natural gut microbiota in C. elegans raise the possibility that this could be a novel model system for microbiome and trans-kingdom interaction studies. Here we review studies of C. elegans host-microbe interactions with a particular focus on the intestine.
机构:
Univ Calif San Diego, Div Biol Sci, Sect Cell & Dev Biol, La Jolla, CA 92093 USAUniv Calif San Diego, Div Biol Sci, Sect Cell & Dev Biol, La Jolla, CA 92093 USA
Cohen, Lianne B.
Troemel, Emily R.
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Univ Calif San Diego, Div Biol Sci, Sect Cell & Dev Biol, La Jolla, CA 92093 USAUniv Calif San Diego, Div Biol Sci, Sect Cell & Dev Biol, La Jolla, CA 92093 USA