Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians

Epidemiologic studies suggest an independent positive association of elevated serum uric acid with essential hypertension. However, to date, limited information is available in the old population. In the present study, we included 832 unrelated Chinese nonagenarians/centenarians (269 men and 563 women; ranged in age from 90 to 108 years (mean, 94.6 +/- 4.0)). The mean serum uric acid level was 320 mu mol l(-1) (standard deviation 87 mu mol l(-1)). After adjustment for age, body mass index, waist-to-hip ratio, smoking habits, tea habits, alcohol consumption, fasting plasma glucose, plasma lipids and serum creatinine, the odds ratio comparing the highest with lowest quartile of serum uric acid were 0.67 (95% confidence interval (CI), 0.33-1.21) and 1.36 (95% CI, 0.88-2.22) in men and women, respectively. When compared with normotensive subjects, we did not observe statistical higher serum uric acid levels in subjects with hypertension. In summary, we found that serum uric acid level is not directly correlated with hypertension among Chinese nonagenarians/centenarians.