A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

被引：64

作者：

Arshad, Tanzeela ^{[1
]}

Mansur, Fizzah ^{[1
]}

Palek, Richard ^{[2
,3
]}

Manzoor, Sobia ^{[1
,3
]}

Liska, Vaclav ^{[2
,3
]}

机构：

[1] Natl Univ Sci & Technol, Atta Ur Rahman Sch Appl Biosci, Mol Virol & Immunol Res Grp, Islamabad, Pakistan

[2] Charles Univ Prague, Fac Med Pilsen, Dept Surg, Plzen, Czech Republic

[3] Charles Univ Prague, Fac Med Pilsen, Biomed Ctr, Lab Canc Treatment & Tissue Regenerat, Prague, Czech Republic

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

关键词：

IL22-producing cells; wound healing-physiopathology; tissue regeneration; carcinogenesis and metastasis; innate immune response and inflammation; INNATE LYMPHOID-CELLS; CD4(+) T-CELLS; INTESTINAL EPITHELIAL-CELLS; ARYL-HYDROCARBON RECEPTOR; MUCOSAL HOST-DEFENSE; LECTIN REGIII-GAMMA; A VIRUS-INFECTION; X-RAY-DIFFRACTION; INDUCIBLE FACTOR; GASTRIC-CANCER;

D O I：

10.3389/fimmu.2020.02148

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Wound healing and tissue regeneration is an intricate biological process that involves repair of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing and tissue regeneration highly overlap with cancer causing pathways. Usually, subsequent tissue damage events include release of a number of cytokines to accomplish post-trauma restoration. IL-22 is one of the cytokines that are immediately produced to initiate immune response against several tissue impairments. IL-22 is a fundamental mediator in inflammation, mucous production, protective role against pathogens, wound healing, and tissue regeneration. However, accumulating evidence suggests pivotal role of IL-22 in instigation of various cancers due to its pro-inflammatory and tissue repairing activity. In this review, we summarize how healing effects of IL-22, when executed in an uncontrollable fashion can lead to carcinogenesis.

引用

页数：17

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