CD3+ CD8+ CD161high Tc17 cells are depleted in HIV-infection

被引：21
|
作者：
Gaardbo, Julie Christine [1 ,2 ]
Hartling, Hans Jakob [1 ,2 ]
Thorsteinsson, Kristina [3 ]
Ullum, Henrik [2 ]
Nielsen, Susanne Dam [1 ]
机构：
[1] Univ Copenhagen Hosp, Rigshosp, Dept Infect Dis, Viroimmunol Res Grp, Copenhagen, Denmark
[2] Rigshosp, Dept Clin Immunol, DK-2100 Copenhagen, Denmark
[3] Univ Copenhagen Hosp, Hvidovre Hosp, Dept Infect Dis, Copenhagen, Denmark
来源：
AIDS | 2013年 / 27卷 / 04期
关键词：
T-CELLS; CD161; EXPRESSION;
D O I：
10.1097/QAD.0b013e32835b8cb3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CD8(+) Tc17 cells with pro-inflammatory properties have only recently been acknowledged, and Tc17 cells in HIV-infection are not described. CD3(+) CD8(+) CD161(high) Tc17 cells and the production of interleukin (IL)-17 were examined in untreated and treated HIV-infected patients, HIV-hepatitis C virus co-infected patients, and healthy controls. Depletion of CD3(+) CD8(+) CD161(high) Tc17 cells and diminished production of IL-17 in HIV-infected patients were found. The level of Tc17 cells was associated with the CD4(+) cell count in treated patients.
引用
收藏
页码：659 / 662
页数：4
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