A review of neurobiological vulnerability factors and treatment implications for comorbid tobacco dependence in schizophrenia

被引：78

作者：

Wing, Victoria C. ^{[1
,2
]}

Wass, Caroline E. ^{[1
,2
]}

Soh, Debra W. ^{[1
]}

George, Tony P. ^{[1
,2
]}

机构：

[1] Ctr Addict & Mental Hlth, Schizophrenia Program, Toronto, ON M5T 1R8, Canada

[2] Univ Toronto, Dept Psychiat, Addict Psychiat Program, Toronto, ON, Canada

来源：

ADDICTION REVIEWS | 2012年 / 1248卷

关键词：

cigarette smoking; nicotine; schizophrenia; cognition; self-medication; addiction vulnerability; VENTRAL TEGMENTAL AREA; TRANSCRANIAL MAGNETIC STIMULATION; NICOTINIC ACETYLCHOLINE-RECEPTORS; DOPAMINE-GLUTAMATE INTERACTIONS; DORSOLATERAL PREFRONTAL CORTEX; SMOKING-CESSATION PROGRAM; PURSUIT EYE-MOVEMENTS; CIGARETTE-SMOKING; SMOOTH-PURSUIT; PREPULSE INHIBITION;

D O I：

10.1111/j.1749-6632.2011.06261.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

There is converging evidence that certain subpopulations of smokers, such as smokers with a serious mental illness like schizophrenia (SCZ), are more likely to become addicted to tobacco and are less likely to quit smoking. This review focuses on the unique risk factors that may increase vulnerability to the initiation and maintenance of nicotine addiction in persons with schizophrenia and other psychotic disorders and also reviews the latest approaches to treating nicotine addiction and schizophrenia based on our neurobiological understanding of central nicotinic receptor systems and related neurotransmitters. In addition, suggestions for future lines of research to better understand reasons for the comorbidity of nicotine addiction in schizophrenia are discussed.

引用

页码：89 / 106

页数：18

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