Synthesis and antibacterial activity of water-soluble chitin derivatives

被引：0
|
作者：
Kim, CH [1 ]
Kim, SY [1 ]
Choi, KS [1 ]
机构：
[1] HANYANG UNIV,COLL ENGN,DEPT IND CHEM,SEOUL 133791,SOUTH KOREA
来源：
POLYMERS FOR ADVANCED TECHNOLOGIES | 1997年 / 8卷 / 05期
关键词：
diethylaminoethyl chitin; diethylaminoethyl chitosan; triethylaminoethyl chitin; antibacterial activity; enzymatic hydrolysis;
D O I：
10.1002/(SICI)1099-1581(199705)8:5<319::AID-PAT645>3.3.CO;2-7
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Diethylaminoethyl-chitin (DEAE-chitin) was synthesized by introducing DEAE groups onto the C(6)-OH in chitin. DEAE-chitin was N-deacetylated by heating in aqueous 10% sodium hydroxide containing sodium borohydride to prepare the diethylaminoethyl-chitosan (DEAE-chitosan). In addition, DEAE-chitin was quaternized with ethyl halide to produce triethylaminoethyl-chitin (TEAE-chitin). Their antibacterial activities were evaluated by using colony count against staphylococcus aureus and E.scherichia coli by means of shake flask method. The antibacterial activity was found to increase in order of DEAE-chitin, DEAE-chitosan, TEAE-chitin. DEAE-chitin was hydrolyzed by enzymes to investigate the effect of molecular weight on its antibacterial activities. The antibacterial activity was dependent on the structure, particularly on the molecular weight of chitin derivatives. (C) 1997 by John Wiley & Sons, Ltd.
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页码：319 / 325
页数：7
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