Development and evaluation of ofloxacin orally disintegrating tablets

被引:8
|
作者
Mohite, Badrinath Pralhadrao [2 ]
Chafle, Sandip Annaji [1 ]
Somasundaram, Jayaprakash [2 ]
Avari, Jasmine Gev [1 ]
机构
[1] Rashtrasant Tukadoji Maharaj Nagpur Univ, Dept Pharmaceut Sci, Nagpur 440033, Maharashtra, India
[2] KM Coll Pharm, Dept Pharmaceut, Madurai, Tamil Nadu, India
关键词
Dispersion time; Indion; 204; Ion exchange resin; Ofloxacin; Orally disintegrating tablets; Tableting properties; Tulsion; 335; Wetting time; RELEASE; RESIN; TASTE; FORMULATION;
D O I
10.1590/S1984-82502012000200005
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Bitter taste of ofloxacin, a broad spectrum bactericidal agent, is masked and orally disintegrating tablets were formulated. The bitter taste is masked by forming complex between drug and weak cation exchange resins, Tulsion 335 and Indion 204. Effect of pH and drug:resin ratio on the drug loading was studied. Maximum drug loading was observed at pH 6. Ratio of 1:2 of drug:resin masked almost complete bitterness of ofloxacin. Formation of complexes was confirmed by IR spectroscopy. Physical characterization of taste masked complexes was carried out. Present work envisages the taste masking of ofloxacin and development of orally disintegrating tablets. The effect of pH and resin quantities on drug loading were studied to find the optimum conditions of drug loading for complete taste masking. Effect of superdisintegrants like sodium starch glycolate, croscarmellose sodium and polyplasdone XL at varying level on physical parameters of compressed tablets was also assessed. The formulations containing 5 % w/w polyplasdone XL showed about 90 % of drug release within 5 minutes. No significant differences were observed in the physical parameters of resinates as well as tablets prepared from Tulsion 335 and Indion 204.
引用
收藏
页码:217 / 225
页数:9
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