Sugar thiourea catalyzed highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinone to β-nitroalkenes

被引：18
|
作者：
Reddy, B. V. Subba [1 ]
Reddy, S. Madhusudana [1 ]
Swain, Manisha [1 ]
机构：
[1] Indian Inst Chem Technol, Lab Xray Crystallog, Ctr Nucl Magnet Resonance, Hyderabad 500607, Andhra Pradesh, India
来源：
RSC ADVANCES | 2013年 / 3卷 / 03期
关键词：
1,4-NAPHTHOQUINONE DERIVATIVES; ANTIFUNGAL; AGENTS; UREA;
D O I：
10.1039/c2ra22270a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinone to beta-nitrostyrenes has been achieved using a novel class of sugar-Cinchona thiourea conjugates. The method offers significant advantages such as low catalyst loading (1 mol%), high enantioselectivity (up to 99% ee), short reaction times and ambient reaction conditions.
引用
收藏
页码：930 / 936
页数：7
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