Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B

被引:55
|
作者
Matsumoto, Akihiro
Tanaka, Eiji [1 ]
Suzuki, Yoshiyuki [2 ]
Kobayashi, Mariko [2 ]
Tanaka, Yasuhito [4 ,5 ]
Shinkai, Noboru [4 ,5 ]
Hige, Shuhei [7 ]
Yatsuhashi, Hiroshi [9 ]
Nagaoka, Shinya [9 ]
Chayama, Kazuaki [10 ]
Tsuge, Masataka [10 ]
Yokosuka, Osamu [11 ]
Imazeki, Fumio [11 ]
Nishiguchi, Shuhei [12 ]
Saito, Masaki [12 ]
Fujiwara, Kei [6 ]
Torii, Nobuyuki [3 ]
Hiramatsu, Naoki [13 ]
Karino, Yoshiyasu [8 ]
Kumada, Hiromitsu [2 ]
机构
[1] Shinshu Univ, Sch Med, Dept Med, Div Gastroenterol, Matsumoto, Nagano 3908621, Japan
[2] Toranomon Gen Hosp, Dept Hepatol, Tokyo, Japan
[3] Tokyo Womens Med Univ, Dept Internal Med & Gastroenterol, Tokyo, Japan
[4] Nagoya City Univ, Grad Sch Med Sci, Dept Virol, Nagoya, Aichi, Japan
[5] Nagoya City Univ, Grad Sch Med Sci, Liver Unit, Nagoya, Aichi, Japan
[6] Nagoya Daini Red Cross Hosp, Gastroenterol Sect, Nagoya, Aichi, Japan
[7] Hokkaido Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Sapporo, Hokkaido, Japan
[8] Sapporo Kosei Gen Hosp, Dept Gastroenterol, Sapporo, Hokkaido, Japan
[9] NHO Nagasaki Med Ctr, Clin Res Ctr, Omura, Japan
[10] Hiroshima Univ, Grad Sch Biomed Sci, Program Biomed Res, Div Frontier Med Sci,Dept Med & Mol Sci, Hiroshima, Japan
[11] Chiba Univ, Grad Sch Med, Dept Med & Clin Oncol, Chiba, Japan
[12] Hyogo Coll Med, Dept Internal Med, Div Hepatobiliary & Pancreat Dis, Nishinomiya, Hyogo, Japan
[13] Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Osaka, Japan
关键词
discontinuation; hepatitis B core-related antigen; hepatitis B surface antigen; nucleos(t)ide analogs; relapse of hepatitis; CORE-RELATED ANTIGEN; CLOSED CIRCULAR DNA; HEPATOCELLULAR-CARCINOMA; SUSTAINED RESPONSE; VIRUS INFECTION; LAMIVUDINE; MANAGEMENT; ENTECAVIR; CESSATION; HBV;
D O I
10.1111/j.1872-034X.2011.00910.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Aim: The factors associated with hepatitis recurrence after discontinuation of nucleos(t)ide analogs (NAs) in patients with chronic hepatitis B were analyzed to predict the risk of relapse more accurately.
引用
收藏
页码:139 / 149
页数:11
相关论文
共 50 条
  • [1] Improving the Prediction of Relapse After Nucleos(t)ide Analogue Discontinuation in Patients With Chronic Hepatitis B
    Song, Do Seon
    Jang, Jeong Won
    Yoo, Sun Hong
    Kwon, Jung Hyun
    Nam, Soon Woo
    Bae, Si Hyun
    Choi, Jong Young
    Yoon, Seung Kew
    CLINICAL INFECTIOUS DISEASES, 2021, 73 (04) : E892 - E903
  • [2] Relapse of Chronic Hepatitis B After Discontinuation of Nucleos(t)ide Analogs: Is the Glass Half Full or Half Empty?
    Reijnders, Jurrien G. P.
    Janssen, Harry L. A.
    HEPATOLOGY, 2013, 58 (06) : 1885 - 1887
  • [3] Biomarkers for predicting nucleos(t)ide analogs discontinuation and hepatitis B virus recurrence after drug withdrawal in chronic hepatitis B patients
    Luo, Mengqi
    Zhou, Bin
    Hou, Jinlin
    Jiang, Deke
    HEPATOLOGY RESEARCH, 2022, 52 (04) : 337 - 351
  • [4] HIGH VIROLOGICAL RELAPSE RATE AFTER NUCLEOS(T)IDE ANALOGUE DISCONTINUATION IN CHRONIC HEPATITIS B
    Chi, H.
    Arends, P.
    Wong, D. K.
    Yim, C.
    Hansen, B. E.
    Janssen, H. L. A.
    JOURNAL OF HEPATOLOGY, 2014, 60 (01) : S436 - S436
  • [5] High relapse rates in HBeAg negative chronic hepatitis B patients after discontinuation of nucleos(t)ide analogues
    Hansen, Bettina E.
    Cornberg, Markus
    Chan, Henry Lik-Yuen
    Arends, Pauline
    Wiegand, Steffen B.
    Brunetto, Maurizia R.
    Janssen, Harry L.
    HEPATOLOGY, 2012, 56 : 412A - 412A
  • [6] The Baseline and On treatment Predictive Factors of Hepatitis B Relapse after Nucleos(t)ide Analogue Discontinuation in Chronic Hepatitis B: A Prospective study
    Kaewdech, Apichat
    Sripongpun, Pimsiri
    Jundee, Sawangpong
    Chamroonkul, Naichaya
    Piratvisuth, Teerha
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2019, 34 : 236 - 236
  • [7] Residual Amount of HBV DNA in Serum is Related to Relapse in Chronic Hepatitis B Patients After Cessation of Nucleos(t)ide Analogs
    Jiang, Jian-ning
    Huang, Zhan-lian
    He, Li-xia
    Huang, Yue-hua
    Su, Ming-hua
    Xie, Rong
    Liang, Yan-xiu
    Fu, Wu-dao
    Huang, Xiao-hong
    Guo, Wen-wen
    Zhong, Shao-hua
    Liu, Zhi-hong
    Li, Shi-hua
    Zhu, Tuo-fu
    Gao, Zhi-liang
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 2015, 49 (04) : 323 - 328
  • [8] Off-Treatment Hepatitis B Virus (HBV) DNA Levels and the Prediction of Relapse After Discontinuation of Nucleos(t)ide Analogue Therapy in Patients With Chronic Hepatitis B: A Prospective Stop Study
    Cao, Jiawei
    Chi, Heng
    Yu, Tao
    Li, Zhandong
    Hansen, Bettina E.
    Zhang, Xiaoyong
    Zhong, Chunxiu
    Sun, Jian
    Hou, Jinlin
    Janssen, Harry L. A.
    Peng, Jie
    JOURNAL OF INFECTIOUS DISEASES, 2017, 215 (04): : 581 - 589
  • [9] Durability after discontinuation of nucleos(t)ide therapy in hepatitis e antigen negative chronic hepatitis B patients
    Cho, Sung Won
    Kim, Soon Sun
    Lee, Dami
    Cho, Jin Hee
    Kim, Kee Bum
    Cheong, Jae Youn
    Cho, Sung Won
    HEPATOLOGY, 2012, 56 : 356A - 356A
  • [10] THE ROLE OF QUANTITATIVE HEPATITIS B SURFACE ANTIGEN, HEPATITIS B CORE-RELATED ANTIGEN AND HEPATITIS B RNA IN PREDICTION OF HEPATITIS B RELAPSE AFTER NUCLEOS(T)IDE ANALOGUE TREATMENT DISCONTINUATION IN CHRONIC HEPATITIS B
    Kaewdech, Apichat
    Sripongpun, Pimsiri
    Jundee, Sawangpong
    Witeerungroj, Teepawit
    Tanaka, Yasuhito
    Tangkijvanich, Pisit
    Piratvisuth, Teerha
    HEPATOLOGY, 2019, 70 : 413A - 414A