Vatairea macrocarpa lectin induces paw edema with leukocyte infiltration

被引：29
|
作者：
Alencar, NMN
Assreuy, AMS
Criddle, DN
Souza, EP
Soares, PMG
Havt, A
Aragao, KS
Bezerra, DP
Ribeiro, RA
Cavada, BS
机构：
[1] Univ Fed Ceara, Fac Med, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, Ceara, Brazil
[2] Univ Fed Ceara, CCS, Mestrado Acad Ciencias Fisiol, BR-60430270 Fortaleza, Ceara, Brazil
来源：
PROTEIN AND PEPTIDE LETTERS | 2004年 / 11卷 / 02期
关键词：
paw edema; leukocyte infiltration; Vatairea macrocarpa lectin;
D O I：
10.2174/0929866043478284
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of paw edema in rats and the possible involvement of leukocytes. Vmac (200 and 400 mug/paw, s.c.) induced a significant time- and dose-dependent paw edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.
引用
收藏
页码：195 / 200
页数：6
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