Predictive and Prognostic Value of the TauProtein in Breast Cancer

被引:0
|
作者
Bonneau, Claire [1 ]
Gurard-Levin, Zachary A. [2 ]
Andre, Fabrice [3 ]
Pusztai, Lajos [4 ]
Rouzier, Roman [1 ,5 ]
机构
[1] Versailles St Quentin En Yvelines Univ, Inst Curie, Dept Breast & Gynaecol Surg, Versailles, France
[2] Inst Curie, Serv Chirurg, CNRS, Dynam Cell Nucleus Unit UMR3664, F-92210 St Cloud, France
[3] Integrated Res Canc Inst Villejuif, UMR Predict Biomarkers & New Mol Therapeut Strate, Paris, France
[4] Yale Univ, Sch Med, Yale Canc Ctr Genet & Genom Program, New Haven, CT USA
[5] Versailles St Quentin En Yvelines Univ, EA Clin Risks & Secur Womens Hlth & Perinatal Hlt, Versailles, France
关键词
Microtubule-associated protein; tau protein; taxanes; chemotherapy sensitivity; cancer treatment; breast cancer; review; PROTEIN-TAU; PACLITAXEL SENSITIVITY; ESTROGEN-RECEPTOR; GENE-EXPRESSION; CHEMOTHERAPY; THERAPY; CYCLOPHOSPHAMIDE; MICROTUBULES; DOXORUBICIN; RESISTANCE;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background/Aim: Predictive markers for response to chemotherapy are required in breast cancer. The Tau protein is a microtubule-associated protein variably expressed in breast cancer. The objective of our study was to describe drug resistance induced by the tau protein, and its predictive and prognostic value in breast cancer. Materials and Methods: Medline and PubMed databases were searched in April 2015 for terms "tau protein", "breast cancer", "chemotherapy sensitivity", "biomarker" and "taxane resistance". Results: In vitro, tau protein competes with taxane for controlling microtubule dynamic and loss of tau expression may render microtubules more vulnerable to the effects of taxanes. High tau protein expression was associated with better prognosis, even after adjustment for grade, hormone receptor and human epidermal growth factor receptor-2 expression, nodal status. The predictive value of the tau protein for sensitivity to taxane is discordant despite there being a trend for an association between low tau expression and increased response rate. Conclusion: Tau protein expression is insufficient for identifying a subset of patients with carcinomas that may benefit more from chemotherapy.
引用
收藏
页码:5179 / 5184
页数:6
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