Predictive and Prognostic Value of the TauProtein in Breast Cancer
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作者:
Bonneau, Claire
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Versailles St Quentin En Yvelines Univ, Inst Curie, Dept Breast & Gynaecol Surg, Versailles, FranceVersailles St Quentin En Yvelines Univ, Inst Curie, Dept Breast & Gynaecol Surg, Versailles, France
Bonneau, Claire
[1
]
Gurard-Levin, Zachary A.
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机构:
Inst Curie, Serv Chirurg, CNRS, Dynam Cell Nucleus Unit UMR3664, F-92210 St Cloud, FranceVersailles St Quentin En Yvelines Univ, Inst Curie, Dept Breast & Gynaecol Surg, Versailles, France
Gurard-Levin, Zachary A.
[2
]
Andre, Fabrice
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机构:
Integrated Res Canc Inst Villejuif, UMR Predict Biomarkers & New Mol Therapeut Strate, Paris, FranceVersailles St Quentin En Yvelines Univ, Inst Curie, Dept Breast & Gynaecol Surg, Versailles, France
Andre, Fabrice
[3
]
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Pusztai, Lajos
[4
]
Rouzier, Roman
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机构:
Versailles St Quentin En Yvelines Univ, Inst Curie, Dept Breast & Gynaecol Surg, Versailles, France
Versailles St Quentin En Yvelines Univ, EA Clin Risks & Secur Womens Hlth & Perinatal Hlt, Versailles, FranceVersailles St Quentin En Yvelines Univ, Inst Curie, Dept Breast & Gynaecol Surg, Versailles, France
Rouzier, Roman
[1
,5
]
机构:
[1] Versailles St Quentin En Yvelines Univ, Inst Curie, Dept Breast & Gynaecol Surg, Versailles, France
[2] Inst Curie, Serv Chirurg, CNRS, Dynam Cell Nucleus Unit UMR3664, F-92210 St Cloud, France
[3] Integrated Res Canc Inst Villejuif, UMR Predict Biomarkers & New Mol Therapeut Strate, Paris, France
[4] Yale Univ, Sch Med, Yale Canc Ctr Genet & Genom Program, New Haven, CT USA
[5] Versailles St Quentin En Yvelines Univ, EA Clin Risks & Secur Womens Hlth & Perinatal Hlt, Versailles, France
Microtubule-associated protein;
tau protein;
taxanes;
chemotherapy sensitivity;
cancer treatment;
breast cancer;
review;
PROTEIN-TAU;
PACLITAXEL SENSITIVITY;
ESTROGEN-RECEPTOR;
GENE-EXPRESSION;
CHEMOTHERAPY;
THERAPY;
CYCLOPHOSPHAMIDE;
MICROTUBULES;
DOXORUBICIN;
RESISTANCE;
D O I:
暂无
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Background/Aim: Predictive markers for response to chemotherapy are required in breast cancer. The Tau protein is a microtubule-associated protein variably expressed in breast cancer. The objective of our study was to describe drug resistance induced by the tau protein, and its predictive and prognostic value in breast cancer. Materials and Methods: Medline and PubMed databases were searched in April 2015 for terms "tau protein", "breast cancer", "chemotherapy sensitivity", "biomarker" and "taxane resistance". Results: In vitro, tau protein competes with taxane for controlling microtubule dynamic and loss of tau expression may render microtubules more vulnerable to the effects of taxanes. High tau protein expression was associated with better prognosis, even after adjustment for grade, hormone receptor and human epidermal growth factor receptor-2 expression, nodal status. The predictive value of the tau protein for sensitivity to taxane is discordant despite there being a trend for an association between low tau expression and increased response rate. Conclusion: Tau protein expression is insufficient for identifying a subset of patients with carcinomas that may benefit more from chemotherapy.
机构:
Univ Hong Kong, Shenzhen Hosp, Div Breast Surg, Shenzhen, Peoples R ChinaUniv Hong Kong, Shenzhen Hosp, Div Breast Surg, Shenzhen, Peoples R China
Shi, Jian
Lian, Chen-Lu
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机构:
Xiamen Univ, Affiliated Hosp 1, Dept Radiat Oncol, Xiamen, Peoples R ChinaUniv Hong Kong, Shenzhen Hosp, Div Breast Surg, Shenzhen, Peoples R China
Lian, Chen-Lu
Chi, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Dept Radiat Oncol, Guangzhou, Peoples R ChinaUniv Hong Kong, Shenzhen Hosp, Div Breast Surg, Shenzhen, Peoples R China
Chi, Feng
Zhou, Ping
论文数: 0引用数: 0
h-index: 0
机构:
Xiamen Univ, Affiliated Hosp 1, Dept Radiat Oncol, Xiamen, Peoples R ChinaUniv Hong Kong, Shenzhen Hosp, Div Breast Surg, Shenzhen, Peoples R China
Zhou, Ping
Lei, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Xiamen Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Xiamen, Peoples R ChinaUniv Hong Kong, Shenzhen Hosp, Div Breast Surg, Shenzhen, Peoples R China
Lei, Jian
Hua, Li
论文数: 0引用数: 0
h-index: 0
机构:
Xiamen Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Xiamen, Peoples R ChinaUniv Hong Kong, Shenzhen Hosp, Div Breast Surg, Shenzhen, Peoples R China
Hua, Li
Wang, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Xiamen Univ, Affiliated Hosp 1, Dept Radiat Oncol, Xiamen, Peoples R ChinaUniv Hong Kong, Shenzhen Hosp, Div Breast Surg, Shenzhen, Peoples R China
Wang, Jun
He, Zhen-Yu
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Dept Radiat Oncol, Guangzhou, Peoples R ChinaUniv Hong Kong, Shenzhen Hosp, Div Breast Surg, Shenzhen, Peoples R China
He, Zhen-Yu
Wu, San-Gang
论文数: 0引用数: 0
h-index: 0
机构:
Xiamen Univ, Affiliated Hosp 1, Dept Radiat Oncol, Xiamen, Peoples R ChinaUniv Hong Kong, Shenzhen Hosp, Div Breast Surg, Shenzhen, Peoples R China