Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity

被引:53
|
作者
Schimming, R
Marmé, D
机构
[1] Univ Clin Freiburg, Dept Oral & Maxillofacial Surg, D-79106 Freiburg, Germany
[2] Tumor Biol Ctr, Inst Mol Med, Freiburg, Germany
关键词
endoglin; squamous cell carcinoma; oral cavity; angiogenesis; endothelia;
D O I
10.1002/hed.10040.abs
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background. Increasing evidence suggests that endoglin (CD105) is a new powerful marker of neovascularization in solid malignancies. To explain the rating of CD105 expression in 51 squamous cell carcinoma of the oral cavity (SCCOC) we analyzed CD105 expression in tumor tissue and adjacent normal healthy mucosa. Methods. Mean CD105 density was quantitated by counting the number of CD105-immunostained blood vessels. The results were compared with clinical parameters like T and N stage, grading, tumor localization, and specific characteristics of patients by means of statistical analysis. Results. Endoglin expression in tumor tissue was significantly higher than in normal healthy mucosa (p <.001). With the exception of T3 (n = 2), a higher T stage was correlated with higher endoglin expression. No statistical correlation was found in the analysis of patient's age, gender, and tumor localization. Conclusions. Endoglin expression is up-regulated in SCCOC compared with normal healthy oral mucosa. Endoglin may have a significant role in the development of SCCOC and might be relatively more specific than commonly used endothelial markers, (C) 2002 John Wiley Sons, Inc.
引用
收藏
页码:151 / 156
页数:6
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