Haplotype variation of estrogen receptor-α (ER-α) gene exon 4 in Turkish sheep breeds

被引：4

作者：

Ozmen, O. ^{[1
]}

Seker, I. ^{[2
]}

Kul, B. Cinar ^{[3
]}

Ertugrul, O. ^{[3
]}

机构：

[1] Firat Univ, Fac Vet, Dept Med Genet, TR-23169 Elazig, Turkey

[2] Firat Univ, Fac Vet, Med Dept Anim Breeding, TR-23169 Elazig, Turkey

[3] Ankara Univ, Fac Vet, Dept Med Genet, TR-06100 Ankara, Turkey

来源：

RUSSIAN JOURNAL OF GENETICS | 2012年 / 48卷 / 10期

关键词：

LITTER SIZE; STATISTICAL TESTS; BETA; POLYMORPHISM; ASSOCIATION; NEUTRALITY; PIGS; ESR1;

D O I：

10.1134/S1022795412100067

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Estrogen receptor a (ER alpha) gene has previously been found related with sexual development and reproduction. In this study, on the basis of the sequences of human, cattle and caprine estrogen receptor alpha (ER alpha) genes, available in the GenBank database, sets of PCR primers were designed and used to amplify the ovine ER alpha gene exon 4 region. We identified six single nucleotide polymorphisms (SNP) in the ER alpha exon 4. Some variations determined for exon 4 g.43A > G, p.T43A; g.49C > T, p.L49F; g.178A > T, p.T178S led to changes in the amino acids, but no amino acid changes were determined in g.18G > C, g.27C > T, g.96G > A. These fragments were deposited in the GenBank database under accession numbers: JF262030-JF262035. It was noted in particular that White Karaman and Awassi breeds were similar to each other, whereas the Chios breed had a different variation.

引用

页码：1015 / 1019

页数：5

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