Modeling of Red Blood Cells in Capillary Flow Using Fluid-Structure Interaction and Gas Diffusion

被引：0

作者：

An, Ling ^{[1
]}

Ji, Fenglong ^{[2
]}

Yin, Yueming ^{[1
]}

Liu, Yi ^{[1
]}

Zhou, Chichun ^{[1
]}

机构：

[1] Dali Univ, Sch Engn, Dali 671003, Peoples R China

[2] Wuyi Univ, Sch Text Mat & Engn, Jiangmen 529020, Peoples R China

来源：

CELLS | 2022年 / 11卷 / 24期

关键词：

diffusion capacity; cell deformation; cell clustering; capacity flow; FINITE-ELEMENT-METHOD; PULMONARY; DEFORMATION; CAPACITY;

D O I：

10.3390/cells11243987

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Red blood cell (RBC) distribution, RBC shape, and flow rate have all been shown to have an effect on the pulmonary diffusing capacity. Through this study, a gas diffusion model and the immersed finite element method were used to simulate the gas diffusion into deformable RBCs running in capillaries. It has been discovered that when RBCs are deformed, the CO flux across the membrane becomes nonuniform, resulting in a reduced capacity for diffusion. Additionally, when compared to RBCs that were dispersed evenly, our simulation showed that clustered RBCs had a significantly lower diffusion capability.

引用

页数：13

共 50 条

[1] A Sharp-Interface Fluid-Structure Interaction Algorithm for Modeling Red Blood Cells
AlMomani, T. D.
Vigmostad, S. C.
Alzube, L. A.
[J]. JORDAN JOURNAL OF MECHANICAL AND INDUSTRIAL ENGINEERING, 2012, 6 (02): : 193 - 198
[2] A monolithic fluid-structure interaction framework applied to red blood cells
Cetin, Ayse
Sahin, Mehmet
[J]. INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, 2019, 35 (02)
[3] FLUID-STRUCTURE INTERACTION MODELING AND VALIDATION OF IDEALIZED LEFT VENTRICULAR BLOOD FLOW
Laughlin, Megan
Stephens, Sam
Jensen, Hanna
Jensen, Morten
Millett, Paul
[J]. PROCEEDINGS OF THE ASME 2020 FLUIDS ENGINEERING DIVISION SUMMER MEETING (FEDSM2020), VOL 3, 2020,
[4] Fluid-structure interaction simulation of aortic blood flow
Crosetto, Paolo
Reymond, Philippe
Deparis, Simone
Kontaxakis, Dimitrios
Stergiopulos, Nikolaos
Quarteroni, Alfio
[J]. COMPUTERS & FLUIDS, 2011, 43 (01) : 46 - 57
[5] Fluid-Structure Interaction Applied to Blood Flow Simulations
Soudah, Eduardo
Onate, Eugenio
Garcia, Jose
Perez, Jorge S.
Mena, Andres
Heindenreich, Elvio
Felix Rodriguez, Jose
Angel Martinez, Miguel
Doblare, Manuel
[J]. ADVANCES IN COMPUTATIONAL VISION AND MEDICAL IMAGE PROCESSING: METHODS AND APPLICATIONS, 2009, 13 : 253 - +
[6] Fluid-Structure interaction applied to blood flow simulations
Perez, J. S.
Soudah, E.
Garcia, J.
Escolano, E.
Onate, E.
Mena, A.
Heidenreich, E.
Rodriguez, J. F.
Doblare, M.
[J]. COMPUTATIONAL VISION AND MEDICAL IMAGING PROCESSING, 2008, : 183 - 189
[7] Modeling of fluid-structure interaction
[J]. Solid Mechanics and its Applications, 2015, 217 : 439 - 478
[8] Modeling fluid-structure interaction
Ortiz, JL
Barhorst, AA
[J]. JOURNAL OF GUIDANCE CONTROL AND DYNAMICS, 1997, 20 (06) : 1221 - 1228
[9] Modeling of fluid-structure interaction
Dowell, EH
Hall, KC
[J]. ANNUAL REVIEW OF FLUID MECHANICS, 2001, 33 : 445 - 490
[10] Numerical modeling of the fluid-structure interaction during blood flow in a flexible stenotic aorta
Issakhov, Alibek
Sabyrkulova, Aidana
Abylkassymova, Aizhan
[J]. INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER, 2024, 158

← 1 2 3 4 5 →