Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response

被引：15
|
作者：
Chahal, Sugandha [1 ]
Hussain, Fathima Shahitha Jahir [1 ]
Yusoff, Mashitah Mohd [1 ]
Rasad, Mohammad Syaiful Bahari Abdull [2 ]
Kumar, Anuj [3 ]
机构：
[1] Univ Malaysia Pahang, Fac Ind Sci & Technol, Kuantan 26300, Pahang, Malaysia
[2] IIUM, Dept Biomed Sci, Kulliyyah Allied Hlth Sci, Kuantan, Pahang, Malaysia
[3] Czech Tech Univ, Dept Bldg Struct, Fac Civil Engn, Prague, Czech Republic
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2017年 / 66卷 / 03期
关键词：
Bone tissue engineering; electrospinning; hydroxyethyl cellulose; nanohydroxyapatite coatings; NEUTRON-ACTIVATION ANALYSIS; BONE TISSUE REGENERATION; NANOFIBROUS SCAFFOLDS; MECHANICAL-PROPERTIES; NANO-HYDROXYAPATITE; TRABECULAR BONE; HEALTHY HUMANS; CALCIUM; MINERALIZATION; RATIO;
D O I：
10.1080/00914037.2016.1190926
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the nHA was formed uniformly over the nanofibers. The nHA mineralization enhanced the tensile strength and reduced the elongation at breakage of scaffolds. The wettability of the nanofibrous scaffolds was significantly improved. The in vitro biocompatibility of scaffolds was evaluated with human osteosarcoma cells. nHA-coated scaffolds had a favorable effect on the proliferation and differentiation of osteosarcoma cell and could be a potential candidate for bone regeneration.
引用
收藏
页码：115 / 122
页数：8
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