The effect of dual PI3K/mTOR inhibitor NVP-BGT226 on cell cycle and survivin and STAT3 gene expression in human pancreatic cancer cell lines

被引:0
|
作者
Glienke, W. [1 ]
机构
[1] Clin Johann Wolfgang Goethe Univ, Frankfurt, Germany
关键词
D O I
10.1200/jco.2011.29.15_suppl.e14523
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
e14523
引用
收藏
页数:1
相关论文
共 50 条
  • [1] The dual PI3K/mTOR inhibitor NVP-BGT226 induces cell cycle arrest and regulates Survivin gene expression in human pancreatic cancer cell lines
    Glienke, Wolfgang
    Maute, Luise
    Wicht, Johannes
    Bergmann, Lothar
    [J]. TUMOR BIOLOGY, 2012, 33 (03) : 757 - 765
  • [2] Activity of NVP-BGT226 in human pancreatic cancer cell lines
    Glienke, W.
    Hausmann, E.
    Bergmann, L.
    [J]. ONKOLOGIE, 2010, 33 : 24 - 24
  • [3] Simultaneous targeting of PI3K and mTOR with NVP-BGT226 is highly effective in multiple myeloma
    Baumann, Philipp
    Schneider, Laura
    Mandl-Weber, Sonja
    Oduncu, Fuat
    Schmidmaier, Ralf
    [J]. ANTI-CANCER DRUGS, 2012, 23 (01) : 131 - 138
  • [4] The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells
    Simioni, Carolina
    Cani, Alice
    Martelli, Alberto M.
    Zauli, Giorgio
    Alameen, Ayman A. M.
    Ultimo, Simona
    Tabellini, Giovanna
    McCubrey, James A.
    Capitani, Silvano
    Neri, Luca M.
    [J]. ONCOTARGET, 2015, 6 (19) : 17147 - 17160
  • [5] Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia
    Kampa-Schittenhelm, K.
    Heinrich, M. C.
    Akmut, F.
    Rasp, K-H
    Kanz, L.
    Schittenhelm, M. M.
    [J]. ONKOLOGIE, 2013, 36 : 44 - 45
  • [6] Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia
    Kampa-Schittenhelm, Kerstin Maria
    Heinrich, Michael Charles
    Akmut, Figen
    Rasp, Katharina Henriette
    Illing, Barbara
    Doehner, Hartmut
    Doehner, Konstanze
    Schittenhelm, Marcus Matthias
    [J]. MOLECULAR CANCER, 2013, 12
  • [7] Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia
    Kerstin Maria Kampa-Schittenhelm
    Michael Charles Heinrich
    Figen Akmut
    Katharina Henriette Rasp
    Barbara Illing
    Hartmut Döhner
    Konstanze Döhner
    Marcus Matthias Schittenhelm
    [J]. Molecular Cancer, 12
  • [8] The combination of gemcitabine with the dual PI3K/mTOR-inhibitor NVP-BEZ235 in human pancreatic cancer cell lines
    Glienke, W.
    Hausmann, E.
    Wicht, J.
    Maute, L.
    Bergmann, L.
    [J]. ONKOLOGIE, 2011, 34 : 57 - 58
  • [9] Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines
    Masuda, Mitsuhiro
    Shimomura, Manami
    Kobayashi, Ken
    Kojima, Shuji
    Nakatsura, Tetsuya
    [J]. ONCOLOGY REPORTS, 2011, 26 (05) : 1273 - 1279
  • [10] Effect of NVP-BEZ235, a dual PI3K/mTOR inhibitor, on chemotherapy and antiangiogenic response in pancreatic cancer
    Ostapoff, Katherine T.
    Awasthi, Niranjan
    Yen, Peter L.
    Zhang, Changhua
    Schwarz, Margaret A.
    Brekken, Rolf A.
    Schwarz, Roderich
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (04)