Development of a 11C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation

被引：60

作者：

Herth, Matthias M. ^{[1
,2
,3
,4
]}

Andersen, Valdemar L. ^{[1
,2
,3
,4
]}

Lehel, Szabolcs ^{[4
]}

Madsen, Jacob ^{[4
]}

Knudsen, Gitte M. ^{[1
,2
]}

Kristensen, Jesper L. ^{[3
]}

机构：

[1] Rigshosp, Ctr Integrated Mol Brain Imaging, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, DK-2100 Copenhagen, Denmark

[3] Univ Copenhagen, Dept Drug Design & Pharmacol, Fac Hlth & Med Sci, DK-2100 Copenhagen, Denmark

[4] Rigshosp, PET & Cyclotron Unit, DK-2100 Copenhagen, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 36期

关键词：

CHEMISTRY;

D O I：

10.1039/c3cc41027g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first C-11-labelled tetrazine and its reaction with trans-cyclooctenol.

引用

页码：3805 / 3807

页数：3

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