Galantamine-ER for the treatment of mild-to-moderate Alzheimer's disease
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作者:
Seltzer, Ben
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Harvard Univ, VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Dept Neurol,Sch Med, Boston, MA 02130 USAHarvard Univ, VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Dept Neurol,Sch Med, Boston, MA 02130 USA
Seltzer, Ben
[1
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[1] Harvard Univ, VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Dept Neurol,Sch Med, Boston, MA 02130 USA
An extended release form of the cholinesterase inhibitor (ChEI) drug galantamine (galantamine-ER) was developed, chiefly to increase adherence to medication regimes in patients with mild-to-moderate Alzheimer's disease (AD). Except for predicted differences in (C-max) and t(max), comparable doses of once daily galantamine-ER and regular, immediate release galantamine, (galantamine-IR), are pharmacologically equivalent. A 24-week randomized, double-blind, placebo-and active-controlled, multicenter phase III trial, which compared galantamine-IR, galantamine-ER and placebo in subjects with mild to moderate AD (mini-mental state examination [MMSE] score range, 10 to 24) showed that both formulations of galantamine were significantly better than placebo in terms of cognition, although not with regard to global change. There was no difference in drug-related adverse events between galantamine-ER and galantamine-IR. Since its release onto the market galantamine-ER has enjoyed wide popularity and a recent surveillance study suggests that it has the highest 1-year persistence rate of all the ChEIs.
机构:
Univ Rochester, Sch Med, AD CARE, Monroe Community Hosp, Rochester, NY 14620 USAUniv Rochester, Sch Med, AD CARE, Monroe Community Hosp, Rochester, NY 14620 USA
Cosman, Kelly M.
Boyle, Llsa L.
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Univ Rochester, Sch Med, AD CARE, Monroe Community Hosp, Rochester, NY 14620 USAUniv Rochester, Sch Med, AD CARE, Monroe Community Hosp, Rochester, NY 14620 USA
Boyle, Llsa L.
Porsteinsson, Anton P.
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Univ Rochester, Sch Med, AD CARE, Monroe Community Hosp, Rochester, NY 14620 USAUniv Rochester, Sch Med, AD CARE, Monroe Community Hosp, Rochester, NY 14620 USA
机构:
IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Geriatr Unit, Foggia, Italy
IRCCS Casa Sollievo Sofferenza, Gerontol Geriatr Res Lab, Foggia, ItalyChiesi Farmaceut, Dept Res & Dev, Parma, Italy
Frisardi, Vincenza
Solfrizzi, Vincenzo
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Univ Bari, Dept Geriatr, Ctr Aging Brain, Memory Unit, Bari, ItalyChiesi Farmaceut, Dept Res & Dev, Parma, Italy
Solfrizzi, Vincenzo
Greco, Antonio
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IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Geriatr Unit, Foggia, Italy
IRCCS Casa Sollievo Sofferenza, Gerontol Geriatr Res Lab, Foggia, ItalyChiesi Farmaceut, Dept Res & Dev, Parma, Italy
Greco, Antonio
Seripa, Davide
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IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Geriatr Unit, Foggia, Italy
IRCCS Casa Sollievo Sofferenza, Gerontol Geriatr Res Lab, Foggia, ItalyChiesi Farmaceut, Dept Res & Dev, Parma, Italy
Seripa, Davide
Pilotto, Alberto
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IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Geriatr Unit, Foggia, Italy
IRCCS Casa Sollievo Sofferenza, Gerontol Geriatr Res Lab, Foggia, Italy
S Antonio Hosp, Azienda ULSS Padova 16, Geriatr Unit, Padua, ItalyChiesi Farmaceut, Dept Res & Dev, Parma, Italy
Pilotto, Alberto
Panza, Francesco
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IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Geriatr Unit, Foggia, Italy
IRCCS Casa Sollievo Sofferenza, Gerontol Geriatr Res Lab, Foggia, ItalyChiesi Farmaceut, Dept Res & Dev, Parma, Italy
机构:
Janssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, JapanJanssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, Japan
Ohnishi, Takashi
Sakiyama, Yojiro
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Janssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, JapanJanssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, Japan
Sakiyama, Yojiro
Okuri, Yuichi
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Janssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, JapanJanssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, Japan
Okuri, Yuichi
Kimura, Yuji
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Janssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, JapanJanssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, Japan
Kimura, Yuji
Sugiyama, Nami
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Janssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, JapanJanssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, Japan
Sugiyama, Nami
Saito, Takayuki
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Janssen Pharmaceut KK, Dept Neurosci, Res & Dev Div, Tokyo 1010065, JapanJanssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, Japan
Saito, Takayuki
Takahashi, Masayoshi
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Janssen Pharmaceut KK, Dept Clin Sci Initiat, Res & Dev Div, Tokyo 1010065, JapanJanssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, Japan
Takahashi, Masayoshi
Kobayashi, Takumi
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Janssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, JapanJanssen Pharmaceut KK, Sci Affairs Div, CNS Sci Dept, Tokyo 1010065, Japan