Monitoring β-Secretase Activity in Living Cells with a Membrane-Anchored FRET Probe

被引：26
|
作者：
Folk, Drew S. [1 ]
Torosian, Justin C. [1 ]
Hwang, Sunhee [1 ]
McCafferty, Dewey G. [1 ]
Franz, Katherine J. [1 ]
机构：
[1] Duke Univ, Dept Chem, Durham, NC 27708 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 43期
基金：
美国国家卫生研究院;
关键词：
Alzheimer's disease; analytical methods; enzymes; Forster resonance energy transfer (FRET); imaging agents; AMYLOID PRECURSOR PROTEIN; ALZHEIMERS-DISEASE; POTENT INHIBITORS; BACE-1; INHIBITORS; ALPHA-SECRETASE; LIPID RAFTS; IN-VITRO; DESIGN; OLIGOMERIZATION; CLEAVAGE;
D O I：
10.1002/anie.201206673
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：10795 / 10799
页数：5
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