Platinum(II) complexes with 5,7-disubstituted-1,2,4-triazolo [1,5-a]pyrimidines: Spectroscopical characterization and cytotoxic activity in vitro

被引：21
|
作者：
Lakomska, Iwona [1 ]
Fandzloch, Marzena [1 ]
Poplawska, Beata [1 ]
Sitkowski, Jerzy [2 ]
机构：
[1] Nicolaus Copernicus Univ, Fac Chem, Gagarina 7, PL-87100 Torun, Poland
[2] Natl Inst Med, PL-00725 Warsaw, Poland
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2012年 / 91卷
关键词：
Platinum complexes; Triazolopyrimidines; N-15; NMR; Pt-195; X-ray; Cytotoxic activity; X-RAY-STRUCTURE; ANTITUMOR-ACTIVITY; CRYSTAL-STRUCTURE; MOLECULAR-STRUCTURES; NMR; PALLADIUM(II); DERIVATIVES; N-15-H-1;
D O I：
10.1016/j.saa.2012.01.050
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Complexes of the types: cis[PtI2(dptp)(2)] (1), cis-[PtI2(NH3)(dptp)] (2), trans-[PtI2(dptp)(dmso)] (3) and trans-[PtI2(dbtp)(dmso)] (4), where dptp=5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine (dptp), dbtp=5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine have been synthesized and characterized by infrared and multinuclear magnetic resonance spectroscopic techniques (H-1, C-13, N-15, Pt-195). In Pt-195 NMR, the cis-diiodo complexes were observed between -2601 ppm and -3261 ppm, while the trans coordination compounds were found at higher field (ca. 4389 ppm). In all cases significant N-15 NMR shielding (92-95 ppm) were observed for N(3) atom indicating this nitrogen atom as a coordination site. The cis complexes have been assayed for antitumor activity in vitro against two human cell lines: A549 (non-small cell lung carcinoma) and T47D (breast cancer). The results indicate a moderate antiproliferative activity of (2) against human cancer lines. (C) 2012 Elsevier B.V. All rights reserved.
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页码：126 / 129
页数：4
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