Synthesis of 2,2-Disubstituted Spirocyclic Pyrrolidines by Intramolecular Dieckmann Condensation

被引：10

作者：

Fominova, Kateryna ^{[1
]}

Diachuk, Taras ^{[1
]}

Sadkova, Iryna V. ^{[1
]}

Mykhailiuk, Pavel K. ^{[1
,2
]}

机构：

[1] Enamine Ltd, Chervonotkatska 78, UA-01103 Kiev, Ukraine

[2] Taras Shevchenko Natl Univ Kyiv, Chem Dept, Volodymyrska 64, UA-01601 Kiev, Ukraine

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 22期

关键词：

Dieckmann condensation; Heterocycles; Pyrrolidine; Amines; Drug design; BUILDING-BLOCKS; SCAFFOLDS; REAGENTS; OXETANES; STEP;

D O I：

10.1002/ejoc.201801750

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel spirocyclic pyrrolidines were synthesized in three steps from cyclic alpha-amino acids with a 3- to 7-membered cycle. The key transformation was the Dieckmann condensation reaction. The described approach opens a door to various novel spirocyclic building blocks for drug design.

引用

页码：3553 / 3559

页数：7

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