Anti-proliferative effect of a compound isolated from Cassia auriculata against human colon cancer cell line HCT 15

被引：11
|
作者：
Esakkirajan, M. [1 ]
Prabhu, N. M. [1 ]
Arulvasu, C. [2 ]
Beulaja, M. [2 ]
Manikandan, R. [1 ]
Thiagarajan, R. [3 ]
Govindaraju, K. [4 ]
Prabhu, D. [4 ]
Dinesh, D. [2 ]
Babu, G. [2 ]
Dhanasekaran, G. [2 ]
机构：
[1] Alagappa Univ, Dept Anim Hlth & Management, Karaikkudi 630003, Tamil Nadu, India
[2] Univ Madras, Dept Zool, Madras 600025, Tamil Nadu, India
[3] SASTRA Univ, Sch Chem & Biotechnol, Dept Biotechnol, Thanjavur 613401, India
[4] Sathyabama Univ, Ctr Ocean Res, Madras 600119, Tamil Nadu, India
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2014年 / 120卷
关键词：
Cassia auriculata; Anti-proliferative; HCT 15 cell line; METASTATIC COLORECTAL-CANCER; PLANTS; PROLIFERATION; BEVACIZUMAB; APOPTOSIS; CURCUMIN; SURVIVAL;
D O I：
10.1016/j.saa.2013.09.102
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
The compound was isolated from leaves of Cassia auriculata and its structure was characterized using high-performance liquid chromatography (HPLC), liquid chromatography mass spectrometry (LC-MS), UV-vis spectroscopy (UV-vis), fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (NMR). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, cytotoxicity, nuclear morphology and lactate dehydrogenase assay of isolated compound was tested against human colon cancer cell line HCT 15. The isolated compound, 4-(4-chlorobenzyl)-2,3,4,5,6,7-hexahydro-7-(2-ethoxyphenyl)benzo[h][1,4,7]triazecin-8(1H)-one at 25 mu g/ml concentration and by 48 h showed 50% inhibition of human colon cancer cells (HCT 15). The results suggest that isolated compound from C auriculata has potential to prevent colon cancer cell line. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：462 / 466
页数：5
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