Inferring functional connectivity using spatial modulation measures of fMRI signals within brain regions of interest

被引：0
|
作者：
Ng, Bernard [1 ]
Abugharbieh, Rafeef [1 ]
McKeown, Martin J. [2 ]
机构：
[1] Univ British Columbia, Dept Elect & Comp Engn, Vancouver, BC V5Z 1M9, Canada
[2] Univ British Columbia, Pacific Parkinsons Res Ctr, Dept Med Neurol, Vancouver, BC V5Z 1M9, Canada
来源：
2008 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO, VOLS 1-4 | 2008年
关键词：
fMRI; functional connectivity; spatial modulation; replicator dynamics; region of interest (ROI);
D O I：
10.1109/ISBI.2008.4541060
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We propose inferring functional connectivity between brain regions by examining the spatial modulation of the blood oxygen level dependent (BOLD) signals within brain regions of interest (ROIs). This is motivated by our previous work, where the spatial distribution of BOLD signals within an ROI was found to be modulated by task. Applying replicator dynamics to our proposed spatial feature time courses on real functional magnetic resonance imaging (fMRI) data detected task-related changes in the composition of the brain's functional networks, whereas using classical mean intensity features resulted in little changes being detected. Thus, our results suggest that intensity is not the only coactivating feature in fMRI data. Instead, spatial modulations may also be used for inferring functional connectivity.
引用
收藏
页码：572 / +
页数：2
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