Hydrogels based on chitosan and dextran as potential drug delivery systems

被引:26
|
作者
Cascone, MG [1 ]
Maltinti, S [1 ]
机构
[1] Univ Pisa, Dipartimento Ingn Chim, I-56126 Pisa, Italy
关键词
D O I
10.1023/A:1008961614439
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The release of human growth hormone (GH) from bioartificial polymeric materials in the form of hydrogels, was measured in vitro for up to 3 weeks. Poly(vinyl-alcohol) (PVA) was blended, in different ratios, with two biological polymers, dextran and chitosan respectively. These blends were used to prepare hydrogels, using a freeze-thawing method. The hydrogels were loaded with GH, and their potential use as delivery systems was investigated, The release with time of PVA, in aqueous medium, was also monitored and evaluated. Scanning electron microscopy was used to investigate the structure of the hydrogels. The results obtained indicated that GH can be released from both dextran/PVA and chitosan/ PVA hydrogels. The initial GH concentration used for sample loading affected the total quantity of GH released but not the pattern of release. The amount of GH released was affected by the content of the biological component. The percentage of PVA released was low but it was, however, related to the content of chitosan and dextran in the blends. (C) 1999 Kluwer Academic Publishers.
引用
收藏
页码:301 / 307
页数:7
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