Tianeptine as a slightly effective therapeutic option for attention-deficit hyperactivity disorder

Objective: Because of the hypotonic side effect of clonidine, the use of tianeptine was studied as an alternative because of its longer excretion half-life, decreased sedative side effects and more selective binding profile. Method: We rated sixty-eight psychiatric outpatients diagnosed with attention-deficit hyperactivity disorder (ADHD) at baseline and while taking tianeptine to determine its efficacy as a treatment for ADHD and used comparisons of Conners' parent ratings within each subject to measure behavioral changes in the subjects. Results: During tianeptine treatment, patients' mean scores improved significantly overall, and also for Conners' Hyperactivity, Inattention and Immaturity factors. Conclusions: This preliminary study indicates that tianeptine might be a slightly effective beneficial and useful treatment for ADHD, reducing hyperactive behaviors and enabling greater attentional ability with minimal side effects. Copyright (C) 2004 S. Karger AG, Basel.